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One bite of a chilli and your mouth is on fire. Except nothing in there is actually burning. ninebrains.app
Your Body

Why chilli feels hot when it isn’t

One bite of a chilli and your mouth is on fire. Except nothing in there is actually burning.

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The aha, in writing

  1. Your mouth is wired with pain-sensing nerves, and on them sits a tiny sensor called TRPV1, the lock on a heat alarm.
  2. Its normal job is to open for painful heat, above about 43 degrees Celsius, and ring the alarm.
  3. Capsaicin, the molecule that makes chilli hot, switches the same sensor on, so your brain gets the same signal and reports heat.

Caterina et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature, 1997.

Resensitization of TRPV1 channels. Frontiers in Cellular Neuroscience, 2023.

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